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Article

SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19.

PloS one - 1 Jan 2021

Nader Danielle, Fletcher Nicola, Curley Gerard F, Kerrigan Steven W

Abstract excerpt

The unprecedented global COVID-19 pandemic has prompted a desperate international effort to accelerate the development of anti-viral candidates. For unknown reasons, COVID-19 infections are associated with adverse cardiovascular complications, implicating that vascular endothelial cells are essential in viral propagation. The etiological pathogen, SARS-CoV-2, has a higher reproductive number and infection rate...

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Share to Caco-2 Cells
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Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrin alphaVbeta3

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Source

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Identifiers

PMID: 34161337
DOI: 10.1371/journal.pone.0253347
PMCID: PMC8221465

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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