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SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein.

Neurobiology of disease - 1 Dec 2021

Khaddaj-Mallat Rayan, Aldib Natija, Bernard Maxime, Paquette Anne-Sophie, Ferreira Aymeric, Lecordier Sarah, Saghatelyan Armen, Flamand Louis, ElAli Ayman

Abstract excerpt

Coronavirus disease 19 (COVID-19) is a respiratory illness caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). COVID-19 pathogenesis causes vascular-mediated neurological disorders via elusive mechanisms. SARS-CoV-2 infects host cells via the binding of viral Spike (S) protein to transmembrane receptor, angiotensin-converting enzyme 2 (ACE2). Although brain pericytes were recently shown to...

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Identifiers

PMID: 34780863
DOI: 10.1016/j.nbd.2021.105561
PMCID: PMC8590447

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