Article

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB

2021-08-02

Abstract excerpt

Vascular endothelial cells (EC) form a critical interface between blood and tissues that maintains whole-body homeostasis. In COVID-19, disruption of the EC barrier results in edema, vascular inflammation, and coagulation, the hallmarks of the severe disease. However, the mechanisms by which EC are dysregulated in COVID-19 are unclear. Here, we show that the spike protein of SARS-CoV-2 alone activates the EC infla...

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Literature Corpus work: 576e31d6-426a-54d3-a4d4-e614dbe142c1
DOI: 10.1101/2021.08.01.454605

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