Article

The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome

2023-11-01

Abstract excerpt

Chronic hepatitis B is a global health problem and current treatments only suppress hepatitis B virus (HBV) infection, highlighting the need for new curative treatments. Oxygen levels influence HBV replication and we previously reported that hypoxia inducible factors (HIFs) activate the basal core promoter to transcribe pre-genomic RNA. Application of a probe-enriched long-read sequencing method to map the HBV tra...

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Literature Corpus work: 1ba87f7a-f3ca-5057-96b7-5c85c8e570d0
DOI: 10.1101/2023.10.31.564956

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