Article

DDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding

2023-04-20

Abstract excerpt

<title>Abstract</title> <p>Hyaline cartilage fibrosis is one of the important reasons for the poor prognosis of advanced osteoarthritis (OA), and is the main factor leading to joint stiffness and deformity. However, the mechanism of hyaline cartilage fibrosis remains largely unclear. Here we found that DDX5, one of the most important members of the DEAD-box RNA helicase family, was dramatically downregulated in t...

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Literature Corpus work: 6949b9a7-72c4-5629-af79-b1ee31e73731
DOI: 10.21203/rs.3.rs-2811502/v1

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