Article

A human-informed multi-patch T-cell vaccine induces broad CD8⁺ immunity and protects against SARS-CoV-2 infection

2026-08-20

Abstract excerpt

<title>Abstract</title> <p> The emergence of SARS-CoV-2 variants has highlighted the need for vaccines that complement Spike-directed immunity by targeting conserved T-cell responses. Here, we developed CoV2-TMEPu, a human-informed multi-patch immunogen integrating conserved and naturally immunodominant regions from structural, accessory and replication-associated SARS-CoV-2 proteins into a single mRNA-lipid nan...

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Literature Corpus work: 8513fdb6-542d-5864-99ab-03ab2be0bfad
DOI: 10.21203/rs.3.rs-10497926/v1

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