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Article

Ezh2 restricts the smooth muscle lineage during mouse lung mesothelial development

31 Aug 2016

Abstract excerpt

During development, the lung mesoderm generates a variety of cell lineages, including airway and vascular smooth muscle. Epigenetic changes in adult lung mesodermal lineages are thought to contribute towards diseases such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease, although the factors that regulate early lung mesoderm development are unknown. We show in mouse that the PRC2...

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PMID: 27578795
DOI: 10.1242/dev.134932

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