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Article

GAK and PRKCD are positive regulators of PRKN-independent mitophagy

20 Oct 2021

Abstract excerpt

The mechanisms involved in programmed or damage-induced removal of mitochondria by mitophagy remains elusive. Here, we have screened for regulators of PRKN-independent mitophagy using an siRNA library targeting 197 proteins containing lipid interacting domains. We identify Cyclin G-associated kinase (GAK) and Protein Kinase C Delta (PRKCD) as regulators of PRKN-independent mitophagy, with both being dispensable...

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PMID: 34671015
DOI: 10.1038/s41467-021-26331-7

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