Article
Evidence for autophagic gridlock in aging and neurodegeneration.
Translational research : the journal of laboratory and clinical medicine - 1 Jul 2014
Bakhoum Mathieu F, Bakhoum Christine Y, Ding Zhixia, Carlton Susan M, Campbell Gerald A, Jackson George R
Abstract excerpt
Autophagy is essential to neuronal homeostasis, and its impairment is implicated in the development of neurodegenerative pathology. However, the underlying mechanisms and consequences of this phenomenon remain a matter of conjecture. We show that misexpression of human tau in Drosophila induces accumulation of autophagic intermediates with a preponderance of large vacuoles, which we term giant autophagic bodies...
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