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Article

The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability

7 Apr 2019

Abstract excerpt

Recent studies indicate a causative relationship between defects in autophagy and dopaminergic neuron degeneration in Parkinson disease (PD). However, it is not fully understood how autophagy is regulated in the context of PD. Here we identify USP24 (ubiquitin specific peptidase 24), a gene located in the PARK10 (Parkinson disease 10 [susceptibility]) locus associated with late onset PD, as a novel negative...

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PMID: 30957634
DOI: 10.1080/15548627.2019.1598754

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