Article

New Atg9 phosphorylation sites regulate autophagic trafficking in glia

2024-07-05

Abstract excerpt

We previously identified a role for dAuxilin (dAux), the fly homolog of Cyclin G-associated kinase (GAK), in glial autophagy contributing to Parkinson’s disease (PD). To further dissect the mechanism, we present evidence here that lack of glial dAux enhanced the phosphorylation of the autophagy-related protein Atg9 at two newly identified threonine residues, T62 and T69. Enhanced Atg9 phosphorylation in the absenc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7cc81724-0819-5ee5-b852-dd84c825e74e
DOI: 10.1101/2024.07.03.601894

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

New Atg9 phosphorylation sites regulate autophagic trafficking in gliaDOI 10.1101/2024.07.03.601894Read

Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in gliaSemantic proximity Read

The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson’s diseaseSemantic proximity Read

dAux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to α-synuclein degradationSemantic proximity Read

The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's diseaseSemantic proximity Read

Differential Regulation of Age-Dependent Neurodegeneration and Buildup Human Phosphorylated Tau in Neurons in <em>Drosophila</em> by ATG14L, ATG6/Beclin 1 and VPS34Semantic proximity Read

Soma-centered control of synaptic autophagy by Rab39-regulated anterograde trafficking of Atg9Semantic proximity Read

BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processesSemantic proximity Read

Doppel induces autophagic stress in prion protein-deficient Purkinje cells.Semantic proximity Read

The broad-spectrum deubiquitinating enzyme inhibitor PR-619 protects retinal ganglion cell and augments parkin-mediated mitophagy in experimental glaucomaSemantic proximity Read

Activation of Atg1 kinase in autophagy by regulated phosphorylation.Semantic proximity Read

Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy.Semantic proximity Read

Tied up: Does altering phosphoinositide-mediated membrane trafficking influence neurodegenerative disease phenotypes?Semantic proximity Read