Article

Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals

2022-05-11

Abstract excerpt

The binding of the SARS-CoV-2 spike to angiotensin-converting enzyme 2 (ACE2) promotes virus entry into the cell. Targeting this interaction represents a promising strategy to generate antivirals. By screening a phage-display library of biosynthetic protein sequences build on a rigid alpha-helicoidal HEAT-like scaffold (named αReps), we selected candidates recognizing the spike receptor binding domain (RBD). Two o...

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Literature Corpus work: faf14c91-f561-5802-bd3d-a724025044a3
DOI: 10.1101/2022.05.10.491295

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