Article

Comparison of SARS-CoV-2 entry inhibitors based on ACE2 receptor or engineered Spike-binding peptides

2023-01-06

Abstract excerpt

With increasing resistance of SARS-CoV-2 variants to antibodies, there is interest in developing entry inhibitors that target essential receptor binding regions of the viral Spike protein and thereby present a high bar for viral resistance. Such inhibitors can be derivatives of the viral receptor, ACE2, or peptides engineered to interact specifically with the receptor-binding pocket. We compared the efficacy of a...

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Identifiers and source

Literature Corpus work: 95d8d237-ccce-543e-a209-5587cb9ef948
DOI: 10.1101/2023.01.05.522964

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