Article

Peptide Antidotes to SARS-CoV-2 (COVID-19)

2020-08-06

Abstract excerpt

<h4>ABSTRACT</h4> The design of an immunogenic scaffold that serves a role in treating a pathogen, and can be rapidly and predictively modeled, has remained an elusive feat. Here, we demonstrate that SARS-BLOCK™ synthetic peptide scaffolds act as antidotes to SARS-CoV-2 spike protein-mediated infection of human ACE2-expressing cells . Critically, SARS-BLOCK™ peptides are able to potently and competitively inhibi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 07bfd8cb-fc10-5e17-98ec-0c97a257c025
DOI: 10.1101/2020.08.06.238915

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Peptide Antidotes to SARS-CoV-2 (COVID-19)DOI 10.1101/2020.08.06.238915Read

Rationally Designed, ACE2 Mimetic Binder to the SARS Cov-2 Associated Spike Protein for COVID-19 Therapeutics and BeyondSemantic proximity Read

Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 VariantsSemantic proximity Read

Inhibition of SARS-CoV-2 pathogenesis by potent peptides designed by the mutation of ACE2 binding region.Semantic proximity Read

The sequence of human ACE2 is suboptimal for binding the S spike protein of SARS coronavirus 2Semantic proximity Read

Peptide Scanning of SARS-CoV and SARS-CoV-2 Spike Protein Subunit 1 Reveals Potential Additional Receptor Binding SitesSemantic proximity Read

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike proteinSemantic proximity Read

A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drugSemantic proximity Read

Computational and Experimental Antibody Affinity and Diagnostic Accuracy Quantification of SARS-CoV-2 SD2 Major Disulfide Loop AnalogSemantic proximity Read

T cell-mediated protection against lethal SARS-CoV-2 challenge by a synthetic long peptide vaccine targeting conserved CD4+ and CD8+ T cell epitopesSemantic proximity Read

An Innovative antibody-based Plug-and-Play strategy for SARS-CoV-2Semantic proximity Read

Comparison of SARS-CoV-2 entry inhibitors based on ACE2 receptor or engineered Spike-binding peptidesSemantic proximity Read

Antiviral Peptides as Promising Therapeutics against SARS-CoV-2Semantic proximity Read