Article

Channelrhodopsin Ion Selectivity Determines Mechanisms and Efficacy of Optogenetic Defibrillation in Human Atria and Ventricles

2026-05-13

Abstract excerpt

Optogenetic defibrillation uses light-gated ion channels to terminate cardiac arrhythmias through targeted illumination. Previous studies assessed the feasibility of using either cation (e.g. ChR2) or anion (e.g. GtACR1) non-selective channels, both of which depolarise resting cardiomyocytes upon photoactivation. In contrast, recently identified light-gated K + -channels (e.g. WiChR) suppress cardiomyocyte activi...

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Literature Corpus work: dbc302f9-491a-52f9-9385-c06d81f75f95
DOI: 10.64898/2026.05.11.724228

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