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Tumor microenvironment characterization in colorectal cancer to identify prognostic and immunotherapy genes signature

18 Aug 2023

Abstract excerpt

BACKGROUND: The tumor microenvironment (TME) plays a crucial role in tumorigenesis, progression, and therapeutic response in many cancers. This study aimed to comprehensively investigate the role of TME in colorectal cancer (CRC) by generating a TMEscore based on gene expression. METHODS: The TME patterns of CRC datasets were investigated, and the TMEscores were calculated. An unsupervised clustering method was...

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PMID: 37596528
DOI: 10.1186/s12885-023-11277-4

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