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Article

Comprehensive evaluation of immunological attributes and immunotherapy responses of positive T cell function regulators in colorectal cancer.

BMC gastroenterology - 1 Oct 2024

Pu Ke, Gao Jingyuan, Feng Yang, Hu Jian, Tang Shunli, Yang Guodong, Xu Chuan

Abstract excerpt

BACKGROUND: Positive regulators of T-cell function (PTFRs), integral to T-cell proliferation and activation, have been identified as potential prognostic markers in colorectal cancer (CRC). Despite this, their role within the tumor microenvironment (TME) and their response to immunotherapy are not yet fully understood. METHODS: This study delved into PTFR-related CRC subtypes by analyzing four independent...

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Identifiers

PMID: 39354362
DOI: 10.1186/s12876-024-03409-2
PMCID: PMC11443709

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