Article

Organobodies: A robust and size-controllable system for generating scalable hiPSC-derived liver organoids for drug toxicity screening

2025-10-21

Abstract excerpt

<h4>Background and aim</h4> Hepatic organoids generated from pluripotent and adult stem cells faithfully mimic the architecture and function of in vivo organs making them powerful tools for preclinical applications such as disease modelling and drug screening. However, developing robust and scalable models capable of preserving liver-specific functions long-term remains technically challenging. <h4>Methods</h4>...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4d6846d5-35b7-5888-9a2a-f479ab7a3013
DOI: 10.1101/2025.10.20.683433

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Organobodies: A robust and size-controllable system for generating scalable hiPSC-derived liver organoids for drug toxicity screeningDOI 10.1101/2025.10.20.683433Read

Mass Generation and Long-term Expansion of Hepatobiliary Organoids from Adult Primary Human HepatocytesSemantic proximity Read

Generation of liver organoids from human induced pluripotent stem cells as liver fibrosis and steatosis modelsSemantic proximity Read

Novel hepatocyte-like liver organoids recapitulate crucial mature hepatic functionsSemantic proximity Read

Liver organoids: established tools for disease modeling and drug developmentSemantic proximity Read

High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell–Derived OrganoidsSemantic proximity Read

A Human Liver Organoid Screening Platform for DILI Risk PredictionSemantic proximity Read

Development of optimised human iPSC-derived hepatocytes with improved liver function for <i>in vitro</i> metabolic disease modelling and toxicity studiesSemantic proximity Read

Regenerative human liver organoids (HLOs) in a pillar/perfusion plate for hepatotoxicity assaysSemantic proximity Read

The Application of Induced Pluripotent Stem Cells Against Liver Diseases: An Update and a ReviewSemantic proximity Read

Evolution of Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.Semantic proximity Read

Enhancing the functional maturity of induced pluripotent stem cell–derived human hepatocytes by controlled presentation of cell–cell interactions in vitroSemantic proximity Read

Robust Expansion and Functional Maturation of Human Hepatoblasts by Chemical StrategySemantic proximity Read