Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of ATP hydrolysis as a key regulator of temozolomide resistance and migratory phenotype of glioblastoma cells.

Biochemical and biophysical research communications - 23 Apr 2022

Scheffel Thamiris Becker, Rockenbach Liliana, Cruz Fernanda Fernandes, Kist Luiza Wilges, Bogo Maurício Reis, Scholl Juliete Nathali, Figueiró Fabrício, Lenz Guido, Morrone Fernanda Bueno

Abstract excerpt

Glioblastoma (GBM) is the most lethal among malignant gliomas. The tumor invasiveness and therapy-resistance are important clinical hallmarks. Growing evidence emphasizes the purinergic signaling contributing to tumor growth. Here we exposed a potential role of extracellular ATPase activity as a key regulator of temozolomide cytotoxicity and the migration process in GBM cells. The inhibition of ATP hydrolysis was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Adenosine Triphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antineoplastic Agents, Alkylating

Share to Brain Neoplasms

Share to Drug Resistance, Neoplasm

Share to Glioblastoma

Share to Hydrolysis

Share to Temozolomide

Source

Identifiers

PMID: 35220010
DOI: 10.1016/j.bbrc.2022.02.062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of ATP hydrolysis as a key regulator of temozolomide resistance and migratory phenotype of glioblastoma cells.PMID 35220010Read ↗

V-ATPase Proton Pump May Take Part to Drug-Resistance Phenotype of Glioma Stem CellsSemantic proximity Read ↗

Vacuolar Proton-Translocating ATPase May Take Part in the Drug Resistance Phenotype of Glioma Stem Cells.Semantic proximity Read ↗

Characterization of purinergic signaling in tumor-infiltrating lymphocytes from lower- and high-grade gliomas.Semantic proximity Read ↗

Ectonucleotidases in Tumor Cells and Tumor-Associated Immune Cells: An OverviewSemantic proximity Read ↗

The Phenomenon of Multidrug Resistance in GlioblastomasSemantic proximity Read ↗

Extracellular ATP and Adenosine in Cancer Pathogenesis and TreatmentSemantic proximity Read ↗

Biology of Glioblastoma Multiforme—Exploration of Mitotic Catastrophe as a Potential Treatment ModalitySemantic proximity Read ↗

Purinergic Signaling in the Hallmarks of CancerSemantic proximity Read ↗

MicroRNA-451 Inhibits Migration of Glioblastoma while Making It More Susceptible to Conventional TherapySemantic proximity Read ↗

Bioenergetics Pathways and Therapeutic Resistance in Gliomas: Emerging Role of MitochondriaSemantic proximity Read ↗

Kinesin spindle protein inhibitors in cancer: a patent review (2008 - present).Semantic proximity Read ↗

Alterations in Cell Motility, Proliferation, and Metabolism in Novel Models of Acquired Temozolomide Resistant GlioblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.