Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effective Elimination of Cancer Stem Cells By a Novel Drug Combination Strategy

6 Nov 2012

Abstract excerpt

Development of effective therapeutic strategies to eliminate cancer stem cells, which play a major role in drug resistance and disease recurrence, is critical to improve cancer treatment outcomes. Our study showed that glioblastoma stem cells (GSCs) exhibited low mitochondrial respiration and high glycolytic activity. These GSCs were highly resistant to standard drugs such as carmustine and temozolomide (TMZ),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Research and Treatments
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23132831
DOI: 10.1002/stem.1273

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effective Elimination of Cancer Stem Cells By a Novel Drug Combination StrategyPMID 23132831Read ↗

Metabolic Alterations in Highly Tumorigenic Glioblastoma CellsSemantic proximity Read ↗

Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging TargetSemantic proximity Read ↗

Metabolic profiling of glioblastoma stem cells reveals pyruvate carboxylase as a critical survival factor and potential therapeutic targetSemantic proximity Read ↗

Cancer Stem Cell Metabolism and Potential Therapeutic TargetsSemantic proximity Read ↗

A ketogenic diet attenuates proliferation and stemness of glioma stem‑like cells by altering metabolism resulting in increased ROS productionSemantic proximity Read ↗

Metabolic Targeting of Cancer Stem CellsSemantic proximity Read ↗

Hallmarks of cancer stem cell metabolismSemantic proximity Read ↗

Targeting cancer stem cells from a metabolic perspectiveSemantic proximity Read ↗

The metabolic landscape of cancer stem cellsSemantic proximity Read ↗

Reactive oxygen species produced by altered tumor metabolism impacts cancer stem cell maintenanceSemantic proximity Read ↗

The Quiescent Metabolic Phenotype of Glioma Stem CellsSemantic proximity Read ↗

Targeting cancer stem‐like cells in glioblastoma and colorectal cancer through metabolic pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.