Article

Programmable RNA-guided endonucleases are widespread in eukaryotes and their viruses

2023-06-14

Abstract excerpt

TnpB proteins are RNA-guided nucleases that are broadly associated with IS200/605 family transposons in prokaryotes. TnpB homologs, named Fanzors, have been detected in genomes of some eukaryotes and large viruses, but their activity and functions in eukaryotes remain unknown. We searched genomes of diverse eukaryotes and their viruses for TnpB homologs and identified numerous putative RNA-guided nucleases that ar...

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Literature Corpus work: fa990655-8368-5c97-b8ae-c2ffbffca090
DOI: 10.1101/2023.06.13.544871

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