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αvβ3-integrin regulates PD-L1 expression and is involved in cancer immune evasion

16 Sept 2019

Abstract excerpt

Tumors utilize a number of effective strategies, including the programmed death 1/PD ligand 1 (PD-1/PD-L1) axis, to evade immune-mediated control of their growth. PD-L1 expression is mainly induced by IFN receptor signaling or constitutively induced. Integrins are an abundantly expressed class of proteins which play multiple deleterious roles in cancer and exert proangiogenic and prosurvival activities. We asked...

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PMID: 31527243
DOI: 10.1073/pnas.1901931116

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