Article

IFN-α and 5-Aza-2’-deoxycytidine enhance the anti-tumor efficacy of a dendritic- cell targeting MIP3a-Gp100-Trp2 DNA vaccine by affecting T-cell recruitment and tumor microenvironment gene expression

2019-01-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The chemokine MIP-3α (CCL20) binds to CCR6 found on immature dendritic cells. DNA vaccines fusing MIP-3α to melanoma-associated antigens have shown improved efficacy and immunogenicity in the B16F10 model. To optimize the therapy, our laboratory has added agents designed to overcome immunoregulatory mechanisms of the tumor microenvironment. Here, we report that the combinati...

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Literature Corpus work: e65e5fde-6cef-57c4-9208-b2ec8be145dd
DOI: 10.1101/531616

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