Article
Host Cell Entry and Neutralization Sensitivity of SARS-CoV-2 Lineages B.1.620 and R.1.
Viruses - 9 Nov 2022
Sidarovich Anzhalika, Krüger Nadine, Rocha Cheila, Graichen Luise, Kempf Amy, Nehlmeier Inga, Lier Martin, Cossmann Anne, Stankov Metodi V, Schulz Sebastian R, Behrens Georg M N, Jäck Hans-Martin, Pöhlmann Stefan, Hoffmann Markus
Abstract excerpt
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) facilitates viral entry into host cells and is the key target for neutralizing antibodies. The SARS-CoV-2 lineage B.1.620 carries fifteen mutations in the S protein and is spread in Africa, the US and Europe, while lineage R.1 harbors four mutations in S and infections were observed in several countries, particularly Japan and...
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