Article

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

2021-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Established in vitro models for SARS-CoV-2 infection are limited and include cell lines of non-human origin and those engineered to overexpress ACE2, the cognate host cell receptor. We identified human H522 lung adenocarcinoma cells as naturally permissive to SARS-CoV-2 infection despite complete absence of ACE2. Infection of H522 cells required the SARS-CoV-2 spike protein, though in contrast...

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Literature Corpus work: d1a7c247-5635-5bae-88e6-fb8b9efa65d9
DOI: 10.1101/2021.03.01.433431

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