Article
Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3.
Nature communications - 9 Oct 2024
Liu Yuanchen, Zhao Xiaoyu, Shi Jialu, Wang Yajie, Liu Huan, Hu Ye-Fan, Hu Bingjie, Shuai Huiping, Yuen Terrence Tsz-Tai, Chai Yue, Liu Feifei, Gong Hua-Rui, Li Jiayan, Wang Xun, Jiang Shujun, Zhang Xiang, Zhang Yanliang, Li Xiangnan, Wang Lei, Hartnoll Madeline, Zhu Tianrenzheng, Hou Yuxin, Huang Xiner, Yoon Chaemin, Wang Yang, He Yixin, Zhou Minmin, Du Lianzhao, Zhang Xiaojuan, Chan Wan-Mui, Chen Lin-Lei, Cai Jian-Piao, Yuan Shuofeng, Zhou Jie, Huang Jian-Dong, Yuen Kwok-Yung, To Kelvin Kai-Wang, Chan Jasper Fuk-Woo, Zhang Bao-Zhong, Sun Lei, Wang Pengfei, Chu Hin
Abstract excerpt
SARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to its global dominance, which remain elusive until today. Here, we find that SARS-CoV-2 JN.1 has a higher...
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