Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7.

doi:10.1016/j.celrep.2021.109292

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Article

Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7.

Cell reports - 29 Jun 2021

Meng Bo, Kemp Steven A, Papa Guido, Datir Rawlings, Ferreira Isabella A T M, Marelli Sara, Harvey William T, Lytras Spyros, Mohamed Ahmed, Gallo Giulia, Thakur Nazia, Collier Dami A, Mlcochova Petra, Duncan Lidia M, Carabelli Alessandro M, Kenyon Julia C, Lever Andrew M, De Marco Anna, Saliba Christian, Culap Katja, Cameroni Elisabetta, Matheson Nicholas J, Piccoli Luca, Corti Davide, James Leo C, Robertson David L, Bailey Dalan, Gupta Ravindra K

Abstract excerpt

We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding affinity to the ACE2 receptor and confer antibody escape. In vitro, we show that, although ΔH69/V70 itself is not an antibody evasion mechanism, it increases infectivity...

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Identifiers

PMID: 34166617
DOI: 10.1016/j.celrep.2021.109292
PMCID: PMC8185188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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