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Article

The open gate of the AMPA receptor forms a Ca2+ binding site critical in regulating ion transport.

Nature structural & molecular biology - 1 Apr 2024

Nakagawa Terunaga, Wang Xin-Tong, Miguez-Cabello Federico J, Bowie Derek

Abstract excerpt

Alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptors (AMPARs) are cation-selective ion channels that mediate most fast excitatory neurotransmission in the brain. Although their gating mechanism has been studied extensively, understanding how cations traverse the pore has remained elusive. Here we investigated putative ion and water densities in the open pore of Ca2+-permeable AMPARs (rat GRIA2...

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Identifiers

PMID: 38409505
DOI: 10.1038/s41594-024-01228-3
PMCID: PMC11536930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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