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Patient derived organoids reveal that PI3K/AKT signalling is an escape pathway for radioresistance and a target for therapy in rectal cancer

2021-09-01

Abstract excerpt

Partial or total resistance to preoperative chemoradiotherapy occurs in more than half of locally advanced rectal cancer patients. Several novel or repurposed drugs have been trialled to improve cancer cell sensitivity to radiotherapy, with limited success. To understand the mechanisms underlying this resistance and target them effectively, we initially compared treatment-naive transcriptomes of radiation-resistan...

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Literature Corpus work
fa59db6b-a542-52cc-ae29-18d14f67d35c
DOI
10.1101/2021.08.31.458326
Open publication

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Patient derived organoids reveal that PI3K/AKT signalling is an escape pathway for radioresistance and a target for therapy in rectal cancerDOI 10.1101/2021.08.31.458326
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