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Unveiling radiobiological traits and therapeutic responses of BRAFV600E-mutant colorectal cancer via patient-derived organoids

11 Mar 2025

Abstract excerpt

Abstract Background Radiotherapy (RT) is an essential treatment for colorectal cancer (CRC), yet the factors influencing radiosensitivity remain unclear. In the quest to enhance the therapeutic efficacy in CRC, the interplay between genetic mutations and RT sensitivity has emerged as a pivotal yet enigmatic area. Methods We harness the fidelity of patient-derived organoids (PDOs) to dissect the molecular...

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PMID: 40069844
DOI: 10.1186/s13046-025-03349-z

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