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Article

Response to neoadjuvant chemoradiotherapy in rectal cancer is associated with RAS/AKT pathway dysregulation and high tumour mutational burden

2020-02-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Pathological complete response (pathCR) in rectal cancer, seen in examination of the pathological specimen post-surgery is the phenomenon whereby a tumour completely regresses under treatment with chemoradiotherapy. This is beneficial as up to 75% of patients do not experience regrowth of the primary tumour, allowing organ preservation and is poorly understood. We aimed to charac...

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Literature Corpus work
75bfc83c-1674-56de-bb34-185709952fd5
DOI
10.1101/2020.02.01.20019794
Open publication

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Response to neoadjuvant chemoradiotherapy in rectal cancer is associated with RAS/AKT pathway dysregulation and high tumour mutational burdenDOI 10.1101/2020.02.01.20019794
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