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Article

BRAFV600E patient derived colon cancer organoids identify biomarkers of response to EGFR and BRAF inhibition and replicate clinical data.

Journal of experimental & clinical cancer research : CR - 25 Mar 2026

Kotarac Anna, Osumi Hiroki, Malt Alexander, Alp Keziban Merve, Jarosch Armin, Werner Johannes, Benary Manuela, Neumann Christopher C M, Yao Ryoji, Mertins Philipp, Eils Roland, Beule Dieter, Sers Christine, Keilholz Ulrich, Ishaque Naveed, Stintzing Sebastian, Vecchione Loredana

Abstract excerpt

BACKGROUND: Drug resistance and lack of predicting biomarkers are a major challenge for cancer therapy. The combination of a BRAF inhibitor (BRAFi) together with an anti-EGFR inhibitor (EGFRi) represents a standard of care approach in BRAFV600E metastatic colorectal cancer (mCRC) patients. However, predictive biomarkers of sensitivity, that could support patient selection for treatment with this combination, are...

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Share to Biomarkers, Tumor
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to ErbB Receptors

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Share to Protein Kinase Inhibitors

Share to Proto-Oncogene Proteins B-raf

Share to PTEN Phosphohydrolase

Source

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Identifiers

PMID: 41882736
DOI: 10.1186/s13046-026-03699-2
PMCID: PMC13063721

Genes

BRAF
EGFR
PIK3CA
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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