Article

Enzyme activity as an actionable axis for small-molecule precision oncology

2026-04-15

Abstract excerpt

Current precision oncology—molecular targeted therapies and immunotherapies—relies on genomic or expressed biomarkers, yet most cancer patients remain ineligible for these treatments. Here, we establish enzyme activity as an actionable and orthogonal axis for precision cancer medicine. Strategic activity-based screening of mouse organs and human clinical specimens with a panel of enzyme-reactive fluorescence probe...

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Literature Corpus work: fa562d66-dd33-539e-94ac-10f0ef8d6b44
DOI: 10.64898/2026.04.14.717586

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