Article

Development of a chemical probe to enable characterization of the casein kinase 1γ subfamily

2025-09-16

Abstract excerpt

The casein kinase 1γ (CK1γ) subfamily, while severely understudied, is implicated in diverse disease-relevant pathways, including WNT signaling and human cytomegalovirus (HCMV) replication. While genetic tools exist to study CK1γ, the selective inhibition of CK1γ through pharmacological means remains underexplored. Chemical probes, or potent and selective inhibitors, remain one of the most powerful pharmacological...

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Literature Corpus work: 8ccad0bf-26b1-5d96-8c89-6c103f5d80f4
DOI: 10.1101/2025.09.10.675406

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