Article

Activatable zymography probes enable in situ localization of protease dysregulation in cancer

2020-07-30

Abstract excerpt

<h4>ABSTRACT</h4> Recent years have seen the emergence of conditionally activated diagnostics and therapeutics that leverage protease-cleavable peptide linkers to enhance their specificity for cancer. However, due to a lack of methods to measure and localize protease activity directly within the tissue microenvironment, the design of protease-activated agents has been necessarily empirical, yielding suboptimal re...

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Literature Corpus work: a505f13c-3ef3-5626-8e4e-9d0780b71ba7
DOI: 10.1101/2020.07.29.227413

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