Article

Impaired KDM2B-mediated PRC1 recruitment to chromatin causes neural stem cell senescence and ASD/ID-like behavioral deficits

2021-09-15

Abstract excerpt

Autism spectrum disorder (ASD) and intellectual disability (ID) are neurodevelopmental diseases associated with various genetic mutations. Recent clinical studies report that chromosomal 12q24.31 microdeletions are associated with human ASD/ID. However, the causality and underlying mechanisms linking 12q24.31 microdeletions to ASD/ID pathogenesis remain undetermined. Here we show Kdm2b , one of the genes located...

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Literature Corpus work: fa52e915-d45c-5a43-98bc-0c4b9a96ef03
DOI: 10.1101/2021.09.13.459918

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Impaired KDM2B-mediated PRC1 recruitment to chromatin causes neural stem cell senescence and ASD/ID-like behavioral deficitsDOI 10.1101/2021.09.13.459918Read

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