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Article

The Role of KDM2A and H3K36me2 Demethylation in Modulating MAPK Signaling During Neurodevelopment.

Neuroscience bulletin - 1 Aug 2024

Ren Zongyao, Tang Haiyan, Zhang Wendiao, Guo Minghui, Cui Jingjie, Wang Hua, Xie Bin, Yu Jing, Chen Yonghao, Zhang Ming, Han Cong, Chu Tianyao, Liang Qiuman, Zhao Shunan, Huang Yingjie, He Xuelian, Liu Kefu, Liu Chunyu, Chen Chao

Abstract excerpt

Intellectual disability (ID) is a condition characterized by cognitive impairment and difficulties in adaptive functioning. In our research, we identified two de novo mutations (c.955C>T and c.732C>A) at the KDM2A locus in individuals with varying degrees of ID. In addition, by using the Gene4Denovo database, we discovered five additional cases of de novo mutations in KDM2A. The mutations we identified...

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Identifiers

PMID: 38060137
DOI: 10.1007/s12264-023-01161-3
PMCID: PMC11306490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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