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The role of the arginine metabolome in pain: implications for sickle cell disease

1 Mar 2016

Abstract excerpt

Sickle cell disease (SCD) is the most common hemoglobinopathy in the US, affecting approximately 100,000 individuals in the US and millions worldwide. Pain is the hallmark of SCD, and a subset of patients experience pain virtually all of the time. Of interest, the arginine metabolome is associated with several pain mechanisms highlighted in this review. Since SCD is an arginine deficiency syndrome, the...

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PMID: 27099528
DOI: 10.2147/jpr.s55571

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