Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic copy number gains of α-synuclein (SNCA) in Parkinson’s disease and multiple system atrophy brains

18 May 2018

Abstract excerpt

The α-synuclein protein, encoded by SNCA, has a key role in the pathogenesis of Parkinson's disease and other synucleinopathies. Although usually sporadic, Parkinson's disease can result from inherited copy number variants in SNCA and other genes. We have hypothesized a role of somatic SNCA mutations, leading to mosaicism, in sporadic synucleinopathies. The evidence for mosaicism in healthy and diseased brain is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Genomic variations and chromosomal abnormalities
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29917054
DOI: 10.1093/brain/awy157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic copy number gains of α-synuclein (SNCA) in Parkinson’s disease and multiple system atrophy brainsPMID 29917054Read ↗

Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencingSemantic proximity Read ↗

Somatic SNCA Copy Number Variants in Multiple System Atrophy are Related to Pathology and InclusionsSemantic proximity Read ↗

Oligodendroglial somatic SNCA copy number gains are associated with inclusions and disease onset in multiple system atrophySemantic proximity Read ↗

Alpha-synuclein gene rearrangements in dominantly inherited parkinsonism: frequency, phenotype, and mechanisms.Semantic proximity Read ↗

Genomic investigation of alpha-synuclein multiplication and parkinsonism.Semantic proximity Read ↗

Comparative genome hybridization array analysis for sporadic Parkinson's disease.Semantic proximity Read ↗

SNCA variants are associated with increased risk for multiple system atrophy.Semantic proximity Read ↗

SNCA locus duplication carriers: from genetics to Parkinson disease phenotypes.Semantic proximity Read ↗

Parkinson's disease and α‐synuclein expressionSemantic proximity Read ↗

alpha-Synuclein gene duplication is present in sporadic Parkinson disease.Semantic proximity Read ↗

Genetics of Synucleinopathies.Semantic proximity Read ↗

Alpha-synuclein missense and multiplication mutations in autosomal dominant Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.