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Article

Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.

The Journal of biological chemistry - 3 Mar 2017

Gerber Hermeto, Wu Fang, Dimitrov Mitko, Garcia Osuna Guillermo M, Fraering Patrick C

Abstract excerpt

Recent evidence suggests involvement of biometal homeostasis in the pathological mechanisms in Alzheimer's disease (AD). For example, increased intracellular copper or zinc has been linked to a reduction in secreted levels of the AD-causing amyloid-β peptide (Aβ). However, little is known about whether these biometals modulate the generation of Aβ. In the present study we demonstrate in both cell-free and...

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PMID: 28096459
DOI: 10.1074/jbc.M116.754101
PMCID: PMC5339758

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APP

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