Article
The English (H6R) familial Alzheimer's disease mutation facilitates zinc-induced dimerization of the amyloid-β metal-binding domain.
Metallomics : integrated biometal science - 1 Mar 2015
Kozin S A, Kulikova A A, Istrate A N, Tsvetkov P O, Zhokhov S S, Mezentsev Y V, Kechko O I, Ivanov A S, Polshakov V I, Makarov A A
Abstract excerpt
Interaction of Zn(2+) with the metal-binding domain of the English (H6R) amyloid-β mutant results in the formation of peptide dimers. The mutation causes the exclusion of His6 from the zinc chelation pattern observed in the intact domain and triggers the assembly of the dimers via zinc ions coordinated by (11)EVHH(14) fragments.
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