Article

In silico optimization of RNA-protein interactions for CRISPR-Cas13-based antimicrobials

2022-06-21

Abstract excerpt

RNA-protein interactions are crucial for diverse biological processes. In prokaryotes, RNA-protein interactions enable adaptive immunity through CRISPR-Cas systems. These defense systems utilize CRISPR RNA (crRNA) templates acquired from past infections to destroy foreign genetic elements through crRNA-mediated nuclease activities of Cas proteins. Thanks to the programmability and specificity of CRISPR-Cas systems...

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Literature Corpus work: f9d29c50-3528-5ee3-ae9f-9a2d39b83ba3
DOI: 10.1101/2022.06.21.496952

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