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Article

Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy.

Scientific reports - 17 Nov 2023

Welch Darcy L, Fridley Brooke L, Cen Ling, Teer Jamie K, Yoder Sean J, Pettersson Fredrik, Xu Liping, Cheng Chia-Ho, Zhang Yonghong, Alexandrow Mark G, Xiang Shengyan, Robertson-Tessi Mark, Brown Joel S, Metts Jonathan, Brohl Andrew S, Reed Damon R

Abstract excerpt

Osteosarcoma is the most common bone sarcoma in children and young adults. While universally delivered, chemotherapy only benefits roughly half of patients with localized disease. Increasingly, intratumoral heterogeneity is recognized as a source of therapeutic resistance. In this study, we develop and evaluate an in vitro model of osteosarcoma heterogeneity based on phenotype and genotype. Cancer cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37978271
DOI: 10.1038/s41598-023-47412-1
PMCID: PMC10656496

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