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Article

The early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies.

The Journal of pathology - 1 Aug 2021

Kovac Michal, Ameline Baptiste, Ribi Sebastian, Kovacova Monika, Cross William, Barenboim Maxim, Witt Olaf, Bielack Stefan, Krieg Andreas, Hartmann Wolfgang, Nathrath Michaela, Baumhoer Daniel

Abstract excerpt

Osteosarcomas are aggressive primary tumors of bone that are typically detected in locally advanced stages; however, which genetic mutations drive the cancer before its clinical detection remain unknown. To identify these events, we performed longitudinal genome-sequencing analysis of 12 patients with metastatic or refractory osteosarcoma. Phylogenetic and molecular clock analyses were carried out next to...

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Identifiers

PMID: 33963544
DOI: 10.1002/path.5699
PMCID: PMC8361660

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