Article
Patient-derived osteosarcoma tumoroid model reveals functional phenotypic diversity with implications for drug responses.
Biofabrication - 9 Feb 2026
Bhatia Sugandha, Claxton Briony, Thompson Erik W, Lowe Martin, Wagels Michael, Nicholls Wayne, Rowell Phil, Hutmacher Dietmar W, McGovern Jacqui A
Abstract excerpt
Osteosarcoma (OS) is the most common primary bone malignancy affecting children and adolescents, for which survival has not improved in more than four decades. The lack of accurate OS preclinical models hinders the understanding of tumor heterogeneity and its interaction with the surrounding extracellular matrix (ECM), limiting the discovery of predictive biomarkers and the development of effective therapies....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.