Article
Molecular and Functional Diversity of Distinct Subpopulations of the Stressed Insulin-Secreting Cell's Vesiculome.
Frontiers in immunology - 1 Jan 2020
Giri Khem Raj, de Beaurepaire Laurence, Jegou Dominique, Lavy Margot, Mosser Mathilde, Dupont Aurelien, Fleurisson Romain, Dubreil Laurence, Collot Mayeul, Van Endert Peter, Bach Jean-Marie, Mignot Gregoire, Bosch Steffi
Abstract excerpt
Beta cell failure and apoptosis following islet inflammation have been associated with autoimmune type 1 diabetes pathogenesis. As conveyors of biological active material, extracellular vesicles (EV) act as mediators in communication with immune effectors fostering the idea that EV from inflamed beta cells may contribute to autoimmunity. Evidence accumulates that beta exosomes promote diabetogenic responses, but...
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