Article

Leptomeningeal Neural Organoid (LMNO) Fusions as Models to Study Meninges-Brain Signaling

2023-12-02

Abstract excerpt

Neural organoids derived from human induced pluripotent stem cells (iPSCs) provide a model to study the earliest stages of human brain development, including neurogenesis, neural differentiation, and synaptogenesis. However, neural organoids lack supportive tissues and some non-neural cell types that are key regulators of brain development. Neural organoids have instead been co-cultured with non-neural structures...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f9a25fc6-91c0-53c4-9fdc-9bbf0af939e3
DOI: 10.1101/2023.12.01.569648

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leptomeningeal Neural Organoid (LMNO) Fusions as Models to Study Meninges-Brain SignalingDOI 10.1101/2023.12.01.569648Read

A cellular atlas of the developing meninges reveals meningeal fibroblast diversity and functionSemantic proximity Read

Morphodynamics of human early brain organoid developmentSemantic proximity Read

Human assembloidsSemantic proximity Read

Multi-Region Brain Organoid –Fusion Organoid with Cerebral, Endothelial and Mid-Hindbrain ComponentsSemantic proximity Read

Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionalitySemantic proximity Read

Human-Mouse Chimeric Brain Models to Study Human Glial-Neuronal and Macroglial-Microglial InteractionsSemantic proximity Read

Single-cell sequencing of human iPSC-derived cerebellar organoids shows recapitulation of cerebellar developmentSemantic proximity Read

An integrative layer-resolved atlas of the adult human meningesSemantic proximity Read

Unified Generation of Regionalized Neural Organoids from Single-Lumen NeuroepitheliumSemantic proximity Read

Fused dorsal-ventral cerebral organoids model human cortical interneuron migrationSemantic proximity Read

Brain organoid-on-a-chip to create multiple domains in forebrain organoidsSemantic proximity Read

Developing Human Pluripotent Stem Cell-Based Cerebral Organoids with a Controllable Microglia Ratio for Modeling Brain Development and PathologySemantic proximity Read