Article

Fused dorsal-ventral cerebral organoids model human cortical interneuron migration

2017-04-26

Abstract excerpt

Development of the forebrain involves the migration of GABAergic interneurons over long distances from ventral into dorsal regions. Although defects in interneuron migration are implicated in neuropsychiatric diseases such as Epilepsy, Autism, and Schizophrenia, model systems to study this process in humans are currently lacking. Here, we describe a method for analyzing human interneuron migration using 3D organoi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 83134871-8ea6-5dac-84f4-cc3166b4a97e
DOI: 10.1101/131250

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fused dorsal-ventral cerebral organoids model human cortical interneuron migrationDOI 10.1101/131250Read

An interface of genetically engineered human forebrain assembloids and polymeric nanofiber scaffolds for multiscale profiling of interneuron migration disordersSemantic proximity Read

Leptomeningeal Neural Organoid (LMNO) Fusions as Models to Study Meninges-Brain SignalingSemantic proximity Read

Endogenous gene tagging with FnCas9 to track and sort neural lineages from 3D cortical organoidsSemantic proximity Read

Brain organoid-on-a-chip to create multiple domains in forebrain organoidsSemantic proximity Read

Time-lapse Confocal Imaging of Migrating Neurons in Organotypic Slice Culture of Embryonic Mouse Brain Using In Utero Electroporation.Semantic proximity Read

Gene Edited Fluorescent Cerebral Organoids to Study Human Brain Function and DiseaseSemantic proximity Read

Generation and Fusion of Human Cortical and Medial Ganglionic Eminence Brain OrganoidsSemantic proximity Read

Extrinsic regulation of interneuron specification and migrationSemantic proximity Read

Gene edited fluorescent cerebral organoids to study human brain function and diseaseSemantic proximity Read

3D organoids containing endothelial and neural cells generation by serial inductions of differentiation on human iPSC-derived embryoid bodiesSemantic proximity Read

Characterization of Human Anterior Neural Organoids as a Model for Investigating Cohen SyndromeSemantic proximity Read

Lineage recording reveals dynamics of cerebral organoid regionalizationSemantic proximity Read