Article

Disruption of immunoglobulin heavy and light chain assembly by antisense oligonucleotides impairs protein homeostasis and myeloma cell survival

2023-08-31

Abstract excerpt

<h4>ABSTRACT</h4> Multiple myeloma (MM) is related to the accumulation of malignant plasma cells (PCs) in the bone marrow. MM accounts for approximatively 10% of hematological malignancies and despite major improvement in therapies and outcomes, relapses will virtually occur in all patients. Usually, the disease goes along with an excess production of a monoclonal immunoglobulin (Ig) component by the tumor PC clo...

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Literature Corpus work: 22596656-97a4-5e68-9437-b0be55168f23
DOI: 10.1101/2023.08.29.555385

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