Article

Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition

2020-03-18

Abstract excerpt

<h4>ABSTRACT</h4> LRH-1 is a nuclear receptor that regulates lipid metabolism and homeostasis, making it an attractive target for the treatment of diabetes and non-alcoholic fatty liver disease. Building on recent structural information about ligand binding from our labs, we have designed a series of new LRH-1 agonists that further engage LRH-1 through added polar interactions. While the current synthetic approac...

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Literature Corpus work: f988752c-c50a-51a3-ba42-6dd40fb126a6
DOI: 10.1101/2020.03.16.994400

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